Pain and fatigue in Sjogren's Syndrome


Arthralgia, myalgia, fibromyalgia, and an intermittent polyarthropathy mainly in the small joints are common.

Unfortunately it can not simply be removed. It is a matter of trying to make it more tolerable.

Anti-inflammatory drugs (e.g. ibuprofen) may be helpful for controlling joint pain and is often combined with hydroxychloroquine (200 mg once daily)

Steroids may be required in severe cases.




There is central fatigue associated with weariness - a worn out feeling. This is difficult to treat and can only be 'coped with' - strategies include a period of rest in the afternoon, no late nights, regular sleep time. Fatigue affects approximately 50% of patients with Sjögren's syndrome but is often brought on by hypothyroidism, fibromyalgia, lymphoma, or underlying depression.

There is peripheral fatigue which can be due to inflammation of the muscles.