Pain and fatigue in Sjogren's Syndrome


The common pain experienced in Sjogren's Syndrome is arthralgia, myalgia, fibromyalgia, and an intermittent polyarthritis mainly in the small joints.

Unfortunately these pains can not simply be removed. It is a matter of trying to make them more tolerable.

Anti-inflammatory drugs (e.g. ibuprofen) may be helpful for controlling joint pain and is often combined with hydroxychloroquine (200 mg once daily)

Steroids may be required in severe cases.




There is central fatigue associated with weariness - a worn out feeling. 

This is difficult to treat and can only be 'coped with' - strategies include a period of rest in the afternoon, no late nights, regular sleep time. 

Fatigue affects approximately 50% of patients with Sjögren's syndrome but is often brought on by hypothyroidism, fibromyalgia, lymphoma, or underlying depression.

There is peripheral fatigue which can be due to inflammation of the muscles.