LATEST SJOGREN'S NEWS
Genetic Determinants of Fatigue in Primary Sjögren`s Syndrome – a Genome Wide Association Study

Background/Purpose:

Fatigue is common in primary Sjögren`s syndrome (pSS), but what leads to that fatigue is not fully understood. They hypothesized that there is a genetic basis for fatigue, and that specific gene-variants influence the severity of fatigue.

To investigate this further they performed a genome wide association study of 367 Scandinavian pSS patients. 

They identified genetic variants in RTP4 exceeding the GWS level for association with fatigue. This gene encodes a protein involved in pain processing. Pain is known to influence fatigue, and this finding could point to a possible molecular explanation. ​​​​​​​

The present study is the largest GWAS of fatigue in autoimmune disease, and adds further evidence to a genetic regulation of fatigue.

Read Full Article here.

Significant improvement in Salivary Gland Ultrasound Scores after treatment with rituximab 

In patients with primary Sjogren's syndrome, improvements in salivary gland ultrasound were demonstrated after treatment with rituximab, according to the results of the TRACTISS randomised double-blind multicentre substudy published in the Annals of the Rheumatic Diseases in 2018.

A total of 52 patients (26 treated with rituximab and 26 treated with placebo) from 9 centers completed the baseline visit and 1 or more follow-up visits.

The research showed statistically significant improvement in total ultrasound score (TUS) after rituximab compared with the placebo. 

Primary Sjögren's syndrome (pSS) impact on smell, taste, sexuality and quality of life in female patients: A systematic review and meta-analysis.
378 female participants were included in the study which was reported in Modern Rheumatology in July 2017.
pSS had a negative impact on smell, taste, sexual function and quality of life in the women. The most impact was considered to be on the physical and mental component of the quality of life.  

 rituximab with a peptide epitope