Did you know that Neurological Symptoms Strike One in Five Primary Sjogren Patients according to a 2016 study.


Neurological symptoms seen in SS include:
  • Cognitive dysfunction or brain fog causing problems with verbal recall, basic arithmetic and concentration
  • Chronic inflammatory demyelinating polyradiculoneuropathy CIDP
  • Cranial neuropathies including trigeminal neuropathy or facial nerve palsy 
  • Dementia
  • Distal paresthesias (numbness and tingling in fingers and toes)
  • Encephalopathy
  • Lower motor neuron disease 
  • Motor and sensory loss
  • Myelopathy
  • Neurogenic bladder
  • Optic neuropathy
  • Progressive-multiple sclerosis-like syndrome
  • Seizures 
  • Vasculitis

Neurologic complications: A PRIMER ON THE NEUROLOGICAL COMPLICATIONS OF SJÖGREN’S By Julius Birnbaum, MD Johns Hopkins Neurology-Rheumatology Clinic

The neurological complications of Sjogren’s syndrome are extensive and range from cognitive difficulties to burning toes and feet.                                                                                                                                     The nervous system is divided into two anatomic compartments:

  1. The “Central Nervous System” – or CNS – includes the brain and the spinal cord;
  2. The “Peripheral Nervous System” – or PNS – includes larger and smaller nerves, connecting muscles to the spinal cord.

Sjögren’s syndrome can cause inflammation and damage to both the CNS and PNS.

Prevalence of neurological manifestations in primary Sjogren's syndrome  (PSS) varies widely from 10 to 60%, with pure or predominantly sensory polyneuropathies as the most common neurologic manifestation (e.g. sensory ataxic or small fiber sensory painful neuropathy). 

Mononeuropathy multiplex, polyradiculopathy, symptomatic dysautonomia, cranial neuropathy, myopathy, and central nervous system involvement are less common. PUBMED ARTICLE
Articles on Neurological Symptoms