Types of  Sjogren's Syndrome

 

What is the difference between Primary and Secondary Sjogren's Syndrome?:

 1. Primary - localized mainly to the eyes and mouth

People with primary Sjogren's have a greater chance of extra glandular involvement.


Primary Sjogren's syndrome occurs by itself. 

Secondary Sjogren's syndrome occurs when another connective tissue disease is present.

Primary and secondary Sjogren’s can have the same symptoms. 

In primary Sjogren’s Syndrome, approximately 10 to 20 percent of people have neurological manifestations such as numbness and tingling in their hands and fingers and carpal tunnel syndrome. In many people these may be the initial symptoms when presenting to a doctor.
In primary Sjogren’s Syndrome, approximately 10 to 20 percent of people have neurological manifestations such as numbness and tingling in their hands and fingers, abnormal sweating, and carpal tunnel syndrome. 

In many people these may be the initial symptoms when presenting to a doctor. This can often mean that the doctor does not associate these symptoms with SS as they are expecting dry eyes and dry mouth symptoms when diagnosing SS. 

This may be a contributing factor in the long time it takes many people to get a correct diagnosis.
 

 2. Secondary - systemic - occuring in conjuction with other connective tissue diseases such as lupus or rheumatoid arthritis.



  • Seronegative means that your blood does not produce the antibodies that show up when tested for the presence of an antibody.


  • Antibodies are indicators of autoimmune disease​​​​​​​. Not everyone with Sjogren’s has antibodies to SSA and SSB.  

    "...these antibodies alone do not account for all cases of Sjogren's syndrome, and the presence of anti-CCP and anti-centromere autoantibodies may account for some cases of primary Sjogren's syndrome in patients seronegative for anti-SSA and anti-SSB." MedPage Today 

Seronegative autoimmune diseases.

A close relationship exists between autoimmunity and autoantibodies; despite this, some patients are persistently negative for disease‐specific autoantibodies. These conditions have been defined as seronegative autoimmune diseases. Although the prevalence of seronegative autoimmune diseases is low, they may represent a practical problem because they are often difficult cases. Read more